Saturday, April 5, 2008

Studies Find Genetic Link to Smoking

WASHINGTON (AP) — Scientists say they have pinpointed a genetic link that makes people more likely to become hooked on tobacco, causing them to smoke more cigarettes, making it harder to quit and leading more often to deadly lung cancer.

The discovery by three separate teams of scientists makes the strongest case so far for the biological underpinnings of the addiction of smoking and sheds light on how genetics and cigarettes join forces to cause cancer, experts said. The findings also lay the groundwork for more tailored treatments to quit smoking.

“This is kind of a double-whammy gene,” said Christopher Amos, a professor of epidemiology at the M. D. Anderson Cancer Center in Houston and author of one of the studies. “It also makes you more likely to be dependent on smoking and less likely to quit smoking.”

A smoker who inherits this genetic variation from both parents has an 80 percent greater chance of lung cancer than a smoker without the variants, the researchers reported. And that same smoker on average lights up two extra cigarettes a day and has a much harder time quitting.

The three studies, financed by governments in the United States and Europe, are being published Thursday in the journals Nature and Nature Genetics.

The scientists surveyed genetic markers in more than 35,000 people in Europe, Canada and the United States, zeroing in on the same set of genetic differences. They are not quite sure if what they found is a set of variations in one gene or in three closely connected genes. But they said the result was the same: These genetic quirks increase the risk of addiction and lung cancer.

The studies’ authors disagreed on whether the set of variants directly increased the risk of lung cancer or did so indirectly by causing more smoking.

The genetic variations, which encode nicotine receptors on cells, could eventually help explain some of the mysteries of chain smoking, nicotine addiction and lung cancer that cannot be chalked up to environmental factors, brain biology and statistics, experts said.

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